2-异恶唑啉衍生物的合成、抗菌和抗氧化活性。
Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives.
机构信息
Department of Chemistry, Faculty of Science, University of Ha'il, P.O. Box. 2440, Ha'il 81451, Saudi Arabia.
Department of Chemistry, Faculty of Science, Yarmouk University, P.O. Box.566, Irbid 21163, Jordan.
出版信息
Molecules. 2020 Sep 18;25(18):4271. doi: 10.3390/molecules25184271.
Abstract
A series of derivatives of -3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4'phenyl)thiosemicarbazide () and of -3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (-) were synthesized from -3-(2,4,6-trimethoxyphenyl)-4,5-dihydro-4,5-bis(hydrazenocarbonyl)isoxazole (). The structures of the compounds were elucidated by both elemental and spectral (IR, NMR, and MS) analysis. Compound shows activity against some bacterial species. No antibacterial activities were observed for compounds -. The antioxidant activity of the new compounds has been screened. Compound showed higher antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2'-azino-bis(3-ethylbenzoline-6-sulfonic acid) diammonium salt methods.
摘要
从 -3-(2,4,6-三甲氧基苯基)-4,5-二氢-4,5-双(肼羰基亚甲基)异恶唑 () 合成了一系列 -3-(2,4,6-三甲氧基苯基)-4,5-二氢异恶唑-4,5-双[羰基-(4'苯基)硫代]脒 () 和 -3-(2,4,6-三甲氧基苯基)-4,5-二氢异恶唑-4,5-双(芳甲酰基氨基甲酰基) (-) 的衍生物。通过元素分析和光谱（IR、NMR 和 MS）分析阐明了化合物的结构。化合物 对一些细菌物种表现出活性。化合物 - 没有表现出抗菌活性。新化合物的抗氧化活性已被筛选。使用 DPPH（1,1-二苯基-2-苦基肼）和 ABTS（2'-氮杂-双（3-乙基苯并噻啉-6-磺酸）二铵盐）方法，化合物 表现出更高的抗氧化活性。
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