Goscianska Joanna, Ejsmont Aleksander, Olejnik Anna, Ludowicz Dominika, Stasiłowicz Anna, Cielecka-Piontek Judyta
Department of Chemical Technology, Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Department of Pharmacognosy, Faculty of Pharmacy, Poznań University of Medical Sciences, Święcickiego 4, 61-781 Poznań, Poland.
Materials (Basel). 2020 Sep 18;13(18):4151. doi: 10.3390/ma13184151.
The oxidized ordered mesoporous carbons of cubic and hexagonal structure obtained by two templating methods (soft and hard) were applied for the first time as delivery systems for paracetamol-the most common antipyretic and analgesic drug in the world. The process of carbon oxidation was performed using an acidic ammonium persulfate solution at 60 °C for 6 h. The functionalization was found to reduce the specific surface area and pore volume of carbon materials, but it also led to an increasing number of acidic oxygen-containing functional groups. The most important element and the novelty of the presented study was the evaluation of adsorption and release ability of carbon carriers towards paracetamol. It was revealed that the sorption capacity and the drug release rate were mainly affected by the materials' textural parameters and the total amount of surface functional groups, notably different in pristine and oxidized samples. The adsorption of paracetamol on the surface of ordered mesoporous carbons occurred according to different mechanisms: donor-acceptor complexes and hydrogen bond formation. The adsorption kinetics was assessed using pseudo-first- and pseudo-second-order models. The regression results indicated that the adsorption kinetics was more accurately represented by the pseudo-second-order model. Paracetamol was adsorbed onto the carbon materials studied following the Langmuir type isotherm. The presence of oxygen-containing functional groups on the surface of ordered mesoporous carbons enhanced the amount of paracetamol adsorbed and its release rate. The optimal drug loading capacity and expected release pattern exhibited oxidized ordered mesoporous carbon with a hexagonal structure obtained by the hard template method.
通过两种模板法（软模板法和硬模板法）制备的立方结构和六方结构的氧化有序介孔碳首次被用作对乙酰氨基酚（世界上最常见的解热镇痛药）的递送系统。使用酸性过硫酸铵溶液在60℃下进行6小时的碳氧化过程。发现功能化降低了碳材料的比表面积和孔体积，但也导致酸性含氧官能团数量增加。本研究最重要的元素和新颖之处在于评估碳载体对乙酰氨基酚的吸附和释放能力。结果表明，吸附容量和药物释放速率主要受材料的结构参数和表面官能团总量影响，原始样品和氧化样品有显著差异。对乙酰氨基酚在有序介孔碳表面的吸附通过不同机制发生：供体-受体络合物和氢键形成。使用准一级和准二级模型评估吸附动力学。回归结果表明，吸附动力学用准二级模型能更准确地表示。对乙酰氨基酚按照朗缪尔型等温线吸附在所研究的碳材料上。有序介孔碳表面含氧官能团的存在提高了对乙酰氨基酚的吸附量及其释放速率。通过硬模板法获得的具有六方结构的氧化有序介孔碳表现出最佳的药物负载能力和预期的释放模式。
