Liang Beiyuan, Wang Jing
Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Cancers (Basel). 2020 Sep 18;12(9):2667. doi: 10.3390/cancers12092667.
The gene encodes for a transcription factor with two zinc finger domains and is transcriptionally activated in a subset of myeloid leukemias. In leukemia, the transcriptional activation of usually results from chromosomal rearrangements. Besides leukemia, has also been linked to solid tumors including breast cancer, lung cancer, ovarian cancer and colon cancer. The gene is encoded by the same locus as . While EVI1 functions as a transcription repressor, MDS1/EVI1 acts as a transcription activator. The fusion protein encoded by the chimeric gene, resulting from chromosomal translocations in a subset of chronic myeloid leukemia, exhibits a similar function to EVI1. EVI1 has been shown to regulate cell proliferation, differentiation and apoptosis, whereas the functions of MDS1/EVI1 and AML1/MDS1/EVI1 remain elusive. In this review, we summarize the genetic structures, biochemical properties and biological functions of these proteins in cancer.
该基因编码一种具有两个锌指结构域的转录因子，在一部分髓系白血病中被转录激活。在白血病中，其转录激活通常源于染色体重排。除白血病外，它还与包括乳腺癌、肺癌、卵巢癌和结肠癌在内的实体瘤有关。该基因与另一个基因由同一基因座编码。虽然EVI1作为转录抑制因子发挥作用，但MDS1/EVI1作为转录激活因子发挥作用。由嵌合基因编码的融合蛋白，源于一部分慢性髓系白血病中的染色体易位，表现出与EVI1相似的功能。EVI1已被证明可调节细胞增殖、分化和凋亡，而MDS1/EVI1和AML1/MDS1/EVI1的功能仍不清楚。在本综述中，我们总结了这些蛋白质在癌症中的遗传结构、生化特性和生物学功能。
