Triebig G, Lehrl S, Kinzel W, Erzigkeit H, Galster J V, Schaller K H
Zentralbl Bakteriol Orig B. 1977;164(4):314-77.
Seven clinical healthy volunteers were exposed to trichloroethylene concentration in air with 520 mg/m3 (100 ppm) at an average 6 hours a day on 5 consecutive days. Corresponding volunteers were exposed to a placebo for the same period. --The persons were examined psychopathometrically and biochemically at the beginning and after every day of exposure. The trichloroethylene-metabolites in blood and urine were dated in order to quantify the loads. --Purpose of the psychopathometrical testing methods was the observation, whether a psychological impairment in the sense of a "psychoorganic syndrome" may occur under these exposition-conditions. --Standardized achievement-tests and self-report rating scales were used in order to demonstrate reversible physical provable psychosis that may be possible. Comparing the psychopathometrical results of the exposed and non-exposed volunteers no statistical significant difference was visible in spite of the analytically proved considerable incorporation of the solvent.
七名临床健康志愿者连续五天每天平均暴露于空气中三氯乙烯浓度为520毫克/立方米(100 ppm)的环境中,每天暴露6小时。相应的志愿者在同一时期暴露于安慰剂环境。——在暴露开始时以及每天暴露结束后,对这些人进行心理测量学和生化检查。对血液和尿液中的三氯乙烯代谢物进行测定以量化接触量。——心理测量测试方法的目的是观察在这些暴露条件下是否可能出现“精神器质性综合征”意义上的心理损害。——使用标准化成就测试和自我报告评定量表以证明可能存在的可逆性身体可证实的精神病。尽管经分析证实溶剂有大量摄入,但比较暴露组和未暴露组志愿者的心理测量结果,未发现统计学上的显著差异。