Tavares Ana Maria, Pingarilho Marta, Batista Judite, Viveiros Miguel, Dias Sónia, Toscano Cristina, Gomes Perpétua, Abecasis Ana B
Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.
Laboratório de Microbiologia Clínica e Biologia Molecular, Serviço de Patologia Clínica, Centro Hospitalar Lisboa Ocidental-Hospital Egas Moniz, Lisboa, Portugal.
AIDS Res Hum Retroviruses. 2021 Jan;37(1):34-37. doi: 10.1089/AID.2020.0119. Epub 2020 Oct 19.
HIV and tuberculosis (TB) are among the global deadliest diseases. Migrant populations are particularly vulnerable to these infections. Yet, literature is still scarce on the epidemiology of HIV-TB co-infection among migrants. In this study, we characterized native and migrant HIV patients followed in Portuguese hospitals, who were diagnosed with TB, regarding their sociodemographic, clinical, and genomic characteristics. Among 67 patients with HIV and TB diagnoses, there were 24 migrants, most from sub-Saharan Africa. Most patients had CD4+ T cell counts below 350 cells/μL, and were diagnosed simultaneously for HIV and TB. When compared to natives, migrants presented a higher proportion of non-B HIV-1 infections. Patients infected with these non-B HIV-1 strains presented higher viral loads, which can have an important impact for the transmissibility and pathogenicity of both diseases. Future studies should investigate different HIV strains and consequences for TB and HIV transmission and disease outcomes, especially among vulnerable populations.
人类免疫缺陷病毒（HIV）和结核病（TB）是全球最致命的疾病之一。移民群体尤其容易感染这些疾病。然而，关于移民中HIV-TB合并感染的流行病学的文献仍然很少。在这项研究中，我们对在葡萄牙医院接受随访且被诊断患有结核病的本地和移民HIV患者的社会人口统计学、临床和基因组特征进行了描述。在67例HIV和TB诊断患者中，有24名移民，大多数来自撒哈拉以南非洲。大多数患者的CD4 + T细胞计数低于350个/μL，并且同时被诊断出患有HIV和TB。与本地人相比，移民中非B型HIV-1感染的比例更高。感染这些非B型HIV-1毒株的患者病毒载量更高，这可能对两种疾病的传播性和致病性产生重要影响。未来的研究应调查不同的HIV毒株以及对TB和HIV传播及疾病结局的影响，尤其是在弱势群体中。
