一种来自L.种子的新型生物碱
A novel alkaloid from the seeds of L.
作者信息
Rong Zi-Jian, Gao Xiao-Xu, Hu Gao-Sheng, Yan Ting, Jia Jing-Ming, Wang An-Hua
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
出版信息
Nat Prod Res. 2022 Apr;36(7):1864-1869. doi: 10.1080/14786419.2020.1824226. Epub 2020 Sep 23.
A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of . Their structures were determined to be (-)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (), (-)-lupanine (), (+)-matrine (), (+)-sophoramine (), (+)-lehmannine () and (-)-sophocarpine (). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity effects against five human tumor cell lines were tested by MTT assay. Compound has showed a wide range of cytotoxicity activities against varied tumor cells .
从……的种子中获得了一种新的金雀花碱型生物碱以及五种已知生物碱。它们的结构被确定为(-)-N-(2'-羟基-3',5'-二叔丁基甲苯)-金雀花碱（）、(-)-羽扇豆碱（）、(+)-苦参碱（）、(+)-槐胺碱（）、(+)-莱曼碱（）和(-)-槐果碱（）。通过核磁共振（NMR）、电子圆二色谱（ECD）和高分辨电喷雾电离质谱（HRESIMS）数据分析确定了它们的结构。通过MTT法测试了它们对五种人类肿瘤细胞系的细胞毒性作用。化合物……对多种肿瘤细胞显示出广泛的细胞毒性活性。
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