Andersen P T, Møller-Petersen J, Henneberg E W, Egeblad K
Surgery. 1987 Jul;102(1):25-31.
Myoglobin concentrations in serum and urine were measured in eight patients who underwent successful arterial embolectomy in the femoral or iliac arteries. Median serum myoglobin levels significantly increased after revascularization to a maximum of 4741 micrograms/L (reference range: 0 to 80 micrograms/L) 2 hours postoperatively, with a concomitant and correlated increase in the urine myoglobin concentration. Three days after the operation, serum myoglobin concentrations were still substantially elevated in three patients. None of our patients suffered permanent renal damage, but transient renal impairment was noted in five patients, as evaluated from the serum and urine beta 2-microglobulin concentrations. We found an association between the concentrations of myoglobin in serum and urine (Spearman's rho: 0.66; p less than 0.001) and between the concentrations of myoglobin in urine and beta 2-microglobulin in urine (Spearman's rho: 0.65; p less than 0.001). Our results indicate a transient renal impairment associated with hypermyoglobinemia and myoglobinuria, even after successful arterial embolectomy.
对8例接受了成功的股动脉或髂动脉动脉栓子切除术的患者，测定了其血清和尿液中的肌红蛋白浓度。血运重建后，血清肌红蛋白水平中位数显著升高，术后2小时最高达到4741微克/升（参考范围：0至80微克/升），同时尿肌红蛋白浓度也相应升高且两者相关。术后3天，3例患者的血清肌红蛋白浓度仍显著升高。我们的患者均未出现永久性肾损伤，但根据血清和尿液β2-微球蛋白浓度评估，5例患者出现了短暂性肾功能损害。我们发现血清和尿液中肌红蛋白浓度之间存在关联（Spearman相关系数：0.66；p<0.001），尿液中肌红蛋白浓度与尿液中β2-微球蛋白浓度之间也存在关联（Spearman相关系数：0.65；p<0.001）。我们的结果表明，即使在成功进行动脉栓子切除术后，仍存在与高肌红蛋白血症和肌红蛋白尿相关的短暂性肾功能损害。
