Paris University, Necker Pasteur Center for Infectious Diseases and Tropical Medicine, IHU Imagine, Necker Enfants malades University Hospital, APHP, Paris, France
Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR 2000, Paris, France.
Ann Rheum Dis. 2020 Dec;79(12):1532-1543. doi: 10.1136/annrheumdis-2020-217092. Epub 2020 Sep 22.
Biological therapies have improved the outcomes of several major inflammatory, autoimmune and also neoplastic disorders. Those directed towards cytokines or other soluble mediators, cell-surface molecules or receptors or various components of intracellular signalling pathways may be associated with the occurrence of infections whose diversity depends on the particular immune target. In this context and following a keynote lecture given by one of us at the European League Against Rheumatism meeting on June 2018, a multidisciplinary group of experts deeply involved in the use of targeted and biological therapies in rheumatoid and psoriatic arthritis decided to summarise their recent vision of the immunological basis and epidemiology of infections occurring during targeted and biological therapies, and provide useful indications for their management and prevention.
生物疗法改善了多种主要炎症性、自身免疫性和肿瘤性疾病的预后。针对细胞因子或其他可溶性介质、细胞表面分子或受体或细胞内信号通路的各种成分的生物疗法可能与感染的发生有关，感染的多样性取决于特定的免疫靶点。在这方面，继我们中的一位在 2018 年 6 月举行的欧洲抗风湿病联盟会议上发表主题演讲后，一个由在类风湿关节炎和银屑病关节炎中使用靶向和生物疗法方面具有深入经验的多学科专家小组决定总结他们对靶向和生物疗法期间发生的感染的免疫学基础和流行病学的最新观点，并提供有关其管理和预防的有用建议。
