Department of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, Japan.
Department of Nephrology, Shonan Kamakura General Hospital, Japan.
Intern Med. 2021 Jan 15;60(2):251-257. doi: 10.2169/internalmedicine.5499-20. Epub 2020 Sep 19.
We herein describe an 82-year-old patient who presented with proteinuria and systemic edema. He was diagnosed with minimal change disease (MCD) and was found to have stage III pancreatic cancer. He could not undergo surgical resection due to invasion to the celiac artery and he was thus treated with chemotherapy. After a month of chemotherapy, his proteinuria improved to a normal level. After two months of chemotherapy, computed tomography indicated a partial response to the therapy. MCD can occur as paraneoplastic syndrome in patients with malignant disease, and chemotherapy can be effective for MCD associated with paraneoplastic syndrome.
我们在此描述了一位 82 岁的患者，其表现为蛋白尿和全身水肿。他被诊断为微小病变病（MCD），并发现患有 III 期胰腺癌。由于肿瘤侵犯腹腔动脉，他无法进行手术切除，因此接受了化疗。化疗一个月后，他的蛋白尿恢复正常水平。化疗两个月后，计算机断层扫描显示对治疗有部分反应。MCD 可作为恶性肿瘤患者的副瘤综合征发生，化疗对与副瘤综合征相关的 MCD 可能有效。
