Nakano Yuta, Yoshida Mariko, Muraki Naohiro, Sugita Kouhei, Ishihara Saori, Kumagai Jiro, Fujisawa Hajime
Department of Nephrology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Glomerular Dis. 2022 May 13;2(3):145-150. doi: 10.1159/000525040. eCollection 2022 Jul.
Minimal change disease (MCD), a common cause of primary nephrotic syndrome that accounts for 10%-15% of all primary nephrotic syndrome cases in adults, is frequently associated with malignant lymphoma. However, studies on MCD associated with prostate cancer are scarce.
A 73-year-old male with prostate cancer was referred to our department with hypoalbuminemia and severe proteinuria while waiting for prostatectomy. We diagnosed the patient with nephrotic syndrome and performed a renal biopsy. Renal pathological findings were consistent with those of MCD. The clinical course suggested an association between prostate cancer and MCD as our patient achieved complete remission of MCD after receiving androgen deprivation and radiation therapy for prostate cancer without the use of glucocorticoids or other immunosuppressants.
Although MCD can be associated with solid tumors, MCD associated with prostate cancer is very rare. The current case is the first to directly raise the possibility that secondary MCD may develop due to prostate cancer in some patients.
微小病变病（MCD）是原发性肾病综合征的常见病因，占成人原发性肾病综合征病例的10%-15%，常与恶性淋巴瘤相关。然而，关于与前列腺癌相关的MCD的研究很少。
一名73岁前列腺癌男性患者在等待前列腺切除术时因低白蛋白血症和严重蛋白尿转诊至我科。我们诊断该患者为肾病综合征并进行了肾活检。肾脏病理结果与MCD一致。临床病程提示前列腺癌与MCD之间存在关联，因为我们的患者在接受前列腺癌雄激素剥夺和放射治疗后，未使用糖皮质激素或其他免疫抑制剂，MCD就完全缓解了。
虽然MCD可与实体瘤相关，但与前列腺癌相关的MCD非常罕见。目前这个病例首次直接提出了在某些患者中可能因前列腺癌而发生继发性MCD的可能性。
