Kimura G, Tsuboi N, Nakajima H, Yoshida K, Masugi Y, Akimoto M
Urol Int. 1987;42(1):30-6. doi: 10.1159/000281846.
Inverted papilloma of the ureter is a rare tumor generally considered to be a benign lesion. We present a case of ureteral inverted papilloma with malignant transformation and review the literature. Ten cases of ureteral inverted papillary tumors in Japan and 13 cases of inverted papillary tumors associated with malignancy in the urinary tract in the world literature have been analyzed to define their features. Inverted papillary tumors of the ureter have distinct clinicopathological features, but most are discovered retrospectively after nephroureterectomy. From the standpoint of clinicopathological features, inverted papillary tumor of the ureter should be distinguished from its exophytic counterpart with respect to the treatment. If the tumor can be diagnosed macro- and microscopically during surgery as inverted papilloma or malignant inverted papillary tumor without invasion, partial ureterectomy including the lesion may be recommended. Furthermore, we propose the hypothesis that inverted papillary tumor could be a neoplasm of basal cell origin in the transitional epithelium, termed 'basal cell urothelioma'.
输尿管内翻性乳头状瘤是一种罕见的肿瘤，通常被认为是良性病变。我们报告一例输尿管内翻性乳头状瘤发生恶性转化的病例并复习相关文献。分析了日本的10例输尿管内翻性乳头状肿瘤病例以及世界文献中13例与泌尿道恶性肿瘤相关的内翻性乳头状肿瘤病例，以明确其特征。输尿管内翻性乳头状肿瘤具有独特的临床病理特征，但大多数是在肾输尿管切除术后才得以回顾性发现。从临床病理特征的角度来看，输尿管内翻性乳头状肿瘤在治疗方面应与其外生性对应物相区分。如果在手术中通过大体和显微镜检查能够诊断肿瘤为内翻性乳头状瘤或无浸润的恶性内翻性乳头状肿瘤，可建议行包括病变部位在内的部分输尿管切除术。此外，我们提出一个假说，即内翻性乳头状肿瘤可能是移行上皮中基底细胞起源的肿瘤，称为“基底细胞尿路上皮瘤”。
