Vithana S, De Silva M H A D, Hewawitharana G P
Lady Ridgeway Hospital for Children, Colombo, Sri Lanka.
Deparment of Paedaitrics, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Case Rep Pediatr. 2020 Sep 11;2020:8837607. doi: 10.1155/2020/8837607. eCollection 2020.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction if it is not timely diagnosed and treated. This happens probably following a cascade of immune reactions after the administration of the drug ultimately leading to multiorgan failure and death. Several groups of drugs have been identified as potential aetiologies but the commonest one identified is antiepileptic drugs. The clinical features of DRESS syndrome usually appear several weeks after commencing the offending drug. Initially, fever lymphadenopathy and rash appear followed by hepatitis. Rash is the most prominent feature, and it is a generalized erythematous nonblanching maculopapular rash without the involvement of the mucus membranes or eyes. The rash desquamated over the following days and changed it's context to an exfoliative dermatitis. We report a case of a 10-year-old boy who is one of the twins born to nonconsanguineous parents at 34 weeks of gestation.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征如果不及时诊断和治疗，是一种危及生命的药物不良反应。这可能发生在用药后一系列免疫反应之后，最终导致多器官衰竭和死亡。几组药物已被确定为潜在病因，但最常见的是抗癫痫药物。DRESS综合征的临床特征通常在开始使用致病药物几周后出现。最初，出现发热、淋巴结病和皮疹，随后出现肝炎。皮疹是最突出的特征，是一种全身性红斑性非苍白性斑丘疹，不累及黏膜或眼睛。皮疹在接下来的几天内脱屑，转变为剥脱性皮炎。我们报告一例10岁男孩的病例，他是一对非近亲父母在妊娠34周时出生的双胞胎之一。
