Institut de Malalties Digestives, Hospital Clínic, CIBER de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
Ann Hepatol. 2010 Apr-Jun;9(2):198-201.
The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, also known as DIHS (drug-induced hypersensitivity syndrome), is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can occasionally produce acute liver failure. In this article we present two cases of the DRESS syndrome presenting with severe acute hepatitis, including the first case of DRESS associated with levetiracetam. Although both cases finally resolved with good outcomes, DRESS can lead to acute liver failure and has a bad prognosis when liver damage is present. Rapid diagnosis is crucial since withdrawal of the offending drug is the key of treatment, while the potential role of corticosteroids is discussed.
DRESS 综合征（药物性皮疹伴嗜酸性粒细胞增多和全身症状），又称 DIHS（药物诱导的超敏反应综合征），是一种对多种药物（主要是抗癫痫药和抗生素）的严重特发性反应，偶尔可导致急性肝衰竭。本文介绍了两例 DRESS 综合征伴严重急性肝炎的病例，包括首例与左乙拉西坦相关的 DRESS 综合征。尽管两例患者最终均痊愈，但 DRESS 可导致急性肝衰竭，且存在肝损伤时预后不良。快速诊断至关重要，因为停用致病药物是治疗的关键，同时还讨论了皮质类固醇的潜在作用。
