Lopes Daniel Thomas Pereira, Gomes Samila Marissa Pinheiro, Siqueira Sheila Aparecida Coelho, Frassetto Fernando Pereira, Sampaio Pedro Henrique Martins Arruda, Moreno Cristiane Araujo Martins, Rocha Maria Sheila Guimarães, Estephan Eduardo Paula
Neurology Departament, Hospital Santa Marcelina, Sao Paulo, São Paulo, Brazil.
Pathology Departament, Universidade de Sao Paulo Hospital das Clinicas, Sao Paulo, São Paulo, Brazil.
Thorac Cardiovasc Surg Rep. 2020 Jan;9(1):e33-e36. doi: 10.1055/s-0040-1714075. Epub 2020 Sep 18.
Myasthenia gravis and thymoma are often presented in association with ∼10% of myasthenic cases having concomitant thymoma. Thymic carcinoma is one of the rarest/aggressive human epithelial tumors and has no correlation with myasthenia gravis hitherto. Here is provided a clinical case and review of literature on a very rare association of thymic carcinoma (with no sign of thymoma) and myasthenia gravis (antiacetylcholine receptor antibody positive). Two years after thymectomy, clinical evolution was satisfactory. This clinical case elicits hypothesis that thymic carcinoma may be related with myasthenia gravis, what may have good prognostic from oncologic and neurologic perspectives.
重症肌无力与胸腺瘤常相伴出现，约10%的重症肌无力病例合并胸腺瘤。胸腺癌是人类最罕见/侵袭性最强的上皮性肿瘤之一，迄今与重症肌无力尚无关联。本文报告1例临床病例并回顾文献，该病例为非常罕见的胸腺癌（无胸腺瘤迹象）与重症肌无力（抗乙酰胆碱受体抗体阳性）并存。胸腺切除术后两年，临床病情进展令人满意。该临床病例引发了这样的假设：胸腺癌可能与重症肌无力有关，从肿瘤学和神经学角度来看这可能具有良好的预后。
