Eysselein V E
Z Gastroenterol. 1987 Apr;25 Suppl 1:21-7.
The purpose of this short review is to reveal new aspects of nerval regulation of gastric acid secretion. The complex interactions between humoral, paracrine, neurocrine, neuroendocrine, vagal and sympathetic mechanisms are underlined. The finding that stimulation of the vagus nerves releases bombesin from peptidergic nerve fibers, which causes release of gastrin from endocrine cells in the stomach, demonstrates the complex interaction between nerves and hormones. The target organ, the parietal cell, has receptors for gastrin, acetylcholine and histamine, which potentiate each other regarding stimulation of acid secretion. New findings about the pathophysiology of acid secretion in duodenal ulcer patients are emphasized.
这篇简短综述的目的是揭示胃酸分泌神经调节的新方面。强调了体液、旁分泌、神经分泌、神经内分泌、迷走神经和交感神经机制之间的复杂相互作用。刺激迷走神经会从肽能神经纤维释放蛙皮素，进而导致胃内分泌细胞释放胃泌素，这一发现证明了神经与激素之间的复杂相互作用。靶器官壁细胞具有胃泌素、乙酰胆碱和组胺的受体，它们在刺激胃酸分泌方面相互增强作用。文中强调了十二指肠溃疡患者胃酸分泌病理生理学的新发现。
