Konturek S J
Klin Wochenschr. 1976 Oct 1;54(19):903-10. doi: 10.1007/BF01469003.
Current concepts on the pathophysiology of gastric hypersecretion in duodenal ulcer disease have been presented and the role of vagal nerves and gastrointestinal hormones particularly gastrin has been discussed. Duodenal ulcer patients form a heterogenous group with regard to the gastric acid and pepsin secretion and gastrin release. They may differ from healthy subjects by several wall defined defects including an increased mass of parietal and peptic cells, increased capacity to secrete acid and pepsin, increased vagal drive to the parietal cells, hyperreactivity of antrum, decreased effectiveness of antral and duodenal autoregulatory mechanisms, defective release of secretin, increased gastric emptying and defective removal of gastric acid load from the duodenum. Very little is known what proportion of duodenal ulcer patients suffer from various pathologic disturbences and what are the mechanisms underlying these changes.
本文介绍了十二指肠溃疡病胃分泌过多的病理生理学的当前概念，并讨论了迷走神经和胃肠激素特别是胃泌素的作用。十二指肠溃疡患者在胃酸、胃蛋白酶分泌和胃泌素释放方面构成一个异质性群体。他们可能与健康受试者在几个明确的壁层缺陷方面存在差异，包括壁细胞和主细胞数量增加、分泌酸和胃蛋白酶的能力增强、壁细胞的迷走神经驱动增加、胃窦高反应性、胃窦和十二指肠自身调节机制有效性降低、促胰液素释放缺陷、胃排空增加以及十二指肠胃酸负荷清除缺陷。对于十二指肠溃疡患者中各种病理紊乱的比例以及这些变化背后的机制知之甚少。
