[; ANALYSIS OF CONSUMPTION OF SYSTEM ANTIMICROBIAL DRUGS IN CHILDREN'S HOSPITALS FOR 2015-2017 IN THE REPUBLIC OF KAZAKHSTAN].

The study gives the results of studying the structure of consumption of systemic antimicrobial drugs in children's hospitals of the Republic of Kazakhstan for 2015-2017.; Purpose of the study - To analyze the dynamics and structure of consumption of systemic antibacterial drugs (J01) in children's hospitals.; A retrospective pharmacoepidemiological study in children's hospitals in 5 regions of the Republic of Kazakhstan, using the ATC/DDD methodology according to the WHO ATC/DDD indices with the determination of the number of DDD/100 bed-days (DBD).; The data on the consumption of systemic antibacterial drugs in children's hospitals for 2015-2017 are presented. A study of the consumption of antibacterial drugs for systemic use in children's hospitals in five regions over three years revealed the following:; - high levels of systemic antibacterial drugs consumption were characteristic of children's hospitals in Karaganda and Nur-Sultan, these same hospitals lead in the number of treated patients;; - the most positive indicators of the consumption of systemic antibacterial drugs were noted in the Pavlodar children's hospital, this was due to the opening of a hospital pharmacy department with centralized dispensing of medicines from mid-2016, which allowed a significant decrease in total consumption of systemic antibacterial drugs;; - аn analysis within the J01D group ATC over three years across five regions showed that cephalosporins (cefazolin, cefuroxime, ceftriaxone, ceftazidime) were characterized by the highest levels of consumption. Data of systemic antibacterial drugs, special attention is required with the use of ceftriaxone and ceftazidime, which increase the risk of selection of multi-resistant shatmas;; - reserve systemic antibacterial drugs indicated in the WHO model list of essential medicines for children (2019) were not used, except for the children's hospital in the city of Karaganda, where the indicators were very low (DDD 100 bed days for 2016 amounted to 0.07 DBD and 0.05 DBD in 2017).; Monitoring the consumption of systemic antibacterial drugs using the ATC/DDD methodology with the determination of the number of DDD/100 bed days (DBD) allows you to identify deficiencies in the consumption of antibiotics and evaluate the effectiveness of programs for the rational use of antibiotics. The results will be used to develop a strategy to improve the use of antibacterial agents in children's hospitals.