Universidade do Espírito Santo, Centro de Ciências da Saúde, Departamento de Patologia e Núcleo de Doenças Infecciosas, Vitória, ES, Brasil.
Pontifícia Universidade Católica do Rio Grande do Sul, Escola de Ciências da Saúde, Porto Alegre, RS, Brasil.
Mem Inst Oswaldo Cruz. 2020 Sep 21;115:e200201. doi: 10.1590/0074-02760200201. eCollection 2020.
Angiostrongylus costaricensis is the causative agent of abdominal angiostrongyliasis, a zoonotic infection that may produce severe eosinophilic enterocolitis or hepatitis in humans. Parasites are usually not released in stools and serology has an important role in diagnosis. Since cross-reactivity is demonstrated between A. costaricensis and another metastrongylid worm, A. cantonensis, we tested heterologous recombinant galectin as a probe in an immunochromatographic rapid diagnostic test (ICT-RDT) for detection of anti-A. costaricensis antibodies. Almost all (11/12) positive control sera from A. costaricensis infected patients were positive at ICT RDT. These are preliminary indications that r-galectin ICT-RDT is useful for diagnosing A. costaricensis infection.
中爪哇胃线虫是腹血管圆线虫病的病原体，这是一种人畜共患感染病，可能在人类体内引起严重的嗜酸性肠炎或肝炎。寄生虫通常不会在粪便中释放，血清学在诊断中具有重要作用。由于 A. costaricensis 和另一种类圆线虫 A. cantonensis 之间存在交叉反应，我们测试了异源重组半乳糖凝集素作为免疫层析快速诊断试验（ICT-RDT）中检测抗 A. costaricensis 抗体的探针。几乎所有（11/12）来自 A. costaricensis 感染患者的阳性对照血清在 ICT-RDT 中呈阳性。这些初步表明 r-半乳糖凝集素 ICT-RDT 可用于诊断 A. costaricensis 感染。
