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乳腺囊肿

Breast Cyst

作者信息

Kowalski Andrew, Okoye Eloka

机构信息

Mclaren Macomb

Royal Wolverhampton NHS Trust

PMID:32965867
Abstract

Breast cysts are a very common diagnosis among women and one of the most common reasons for a referral to a breast clinic. They represent the most common cause of breast mass or breast symptoms in general. Breast cysts are part of a larger benign disease process known as fibrocystic disease of the breast. This disease process is a wide spectrum of both fibrous and cystic changes in the breast tissue. The simple breast cyst forms as an aberration in the natural breast development and is composed of an epithelium lined fluid-filled cavity within the surrounding breast parenchyma. They can vary from small microcysts to large macrocysts and can be single or multiple. These cysts can be entirely asymptomatic and only discovered incidentally, or can be symptomatic, presenting as lumps, pain, or associated nipple discharge. Many studies report that in women, the lifetime prevalence of fibrocystic breast disease might be between 70% and 90%. Fibrocystic changes are classified as nonproliferative, proliferative without atypia, or proliferative with atypia. While the pain and palpable mass can be worrisome to patients, pain as a symptom of breast malignancy is exceedingly rare. Furthermore, fibrocystic disease by itself is not strictly a risk factor for the development of breast malignancy. While the simple breast cyst is a nonproliferative benign disease process, atypia (or atypical ductal hyperplasia) in fibrocystic disease does have a malignant potential, and there are other malignant cystic lesions which can occur and can appear very similar in nature. The relationship between fibrocystic changes and breast cancer is complicated and controversial. Because of this, proper diagnosis, treatment, and management of breast cysts are essential.

摘要

乳腺囊肿在女性中是一种非常常见的诊断结果,也是转诊至乳腺专科门诊最常见的原因之一。总体而言,它们是乳腺肿块或乳腺症状最常见的病因。乳腺囊肿是一种更广泛的良性疾病过程的一部分,即乳腺纤维囊性变。这种疾病过程是乳腺组织中纤维性和囊性变化的广泛谱系。单纯性乳腺囊肿是在乳腺自然发育过程中出现的异常,由周围乳腺实质内衬上皮的充满液体的腔组成。它们大小不一,从小的微囊肿到大的巨囊肿,可为单个或多个。这些囊肿可能完全没有症状,只是偶然发现,也可能有症状,表现为肿块、疼痛或伴有乳头溢液。许多研究报告称,女性一生中乳腺纤维囊性变的患病率可能在70%至90%之间。纤维囊性变分为非增生性、增生性无异型性或增生性伴有异型性。虽然疼痛和可触及的肿块可能令患者担忧,但作为乳腺恶性肿瘤症状的疼痛极为罕见。此外,纤维囊性变本身并非严格意义上乳腺恶性肿瘤发生的危险因素。虽然单纯性乳腺囊肿是一种非增生性良性疾病过程,但纤维囊性变中的异型性(或非典型导管增生)确实具有恶变潜能,而且还可能出现其他性质上非常相似的恶性囊性病变。纤维囊性变与乳腺癌之间的关系复杂且存在争议。因此,对乳腺囊肿进行正确的诊断、治疗和管理至关重要。