脊髓非侵入性电刺激和磁刺激的建模研究
Modelling Studies of Non-invasive Electric and Magnetic Stimulation of the Spinal Cord
作者信息
Fernandes Sofia Rita, Salvador Ricardo, de Carvalho Mamede, Miranda Pedro Cavaleiro
机构信息
Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal
Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
Experimental studies on transcutaneous spinal cord direct current and magnetic stimulation (tsDCS and tsMS, respectively) show promising results in the neuromodulation of spinal sensory and motor pathways, with possible clinical application in spinal functional rehabilitation. Modelling studies on the electric field (EF) distribution during tsDCS and tsMS can be powerful tools to understand the underlying biophysics and to guide stimulation protocols for a specific clinical target. In this chapter, we review modelling studies of tsDCS and report on our own modelling findings on tsDCS and tsMS. We discuss the main differences between the EF induced by these two stimulation techniques and the implications for clinical practice, addressing the relevance of modelling studies for more personalized target protocols and individualized dosing.
经皮脊髓直流电刺激和磁刺激（分别为tsDCS和tsMS）的实验研究表明，在脊髓感觉和运动通路的神经调节方面取得了有前景的结果，在脊髓功能康复中可能具有临床应用价值。对tsDCS和tsMS期间电场（EF）分布的建模研究可以成为理解潜在生物物理学以及指导针对特定临床靶点的刺激方案的有力工具。在本章中，我们回顾tsDCS的建模研究，并报告我们自己关于tsDCS和tsMS的建模结果。我们讨论这两种刺激技术所诱导的EF之间的主要差异及其对临床实践的影响，探讨建模研究对于更个性化的靶点方案和个体化剂量的相关性。
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