Chalcogenide-Catalyzed Intermolecular Electrophilic Thio- and Halofunctionalization of -Difluoroalkenes: Construction of Diverse Difluoroalkyl Sulfides and Halides.

Thio- and halodifluoromethylated compounds are an important class of compounds in medicinal chemistry and organic synthesis. Herein, we report a facile method for the construction of these compounds via chalcogenide-catalyzed intermolecular electrophilic thio- and halofunctionalization of -difluoroalkenes. Simple treatment of -difluoroalkenes with electrophilic sulfur/halogen reagents and various - or -nucleophiles affords diverse multifunctionalized thio- and halodifluoromethylated compounds. This reaction features a relatively broad substrate scope, good functional group tolerance, and mild reaction conditions.