Bierich J R
Acta Paediatr Scand Suppl. 1986;325:71-5. doi: 10.1111/j.1651-2227.1986.tb10368.x.
In constitutional delay of growth and adolescence (CDGA), all growth and maturation parameters are delayed by 2-4 years. Provocation tests of hGH secretion give normal values, but spontaneous (endogenous) secretion is low. This can be assessed by measuring night-time hGH secretion, when the differences between normal subjects and CDGA patients are highly significant. Replacement therapy with hGH produced growth spurts in all but one patient, improving their growth prognosis. A new series of 16 CDGA patients has now been treated with hGH for 1-3 years. Catch-up growth was seen during the first year, which decreased to normal growth velocity by the third year. This normal growth rate is still faster than the pretreatment velocity. Although hGH therapy may be effective in CDGA, it may only be justified in cases with psychological problems arising from their short stature.
在体质性生长和青春期延迟（CDGA）中，所有生长和成熟参数均延迟2至4年。生长激素（hGH）分泌的激发试验结果正常，但自发性（内源性）分泌较低。这可以通过测量夜间hGH分泌来评估，此时正常受试者与CDGA患者之间的差异非常显著。除一名患者外，所有患者接受hGH替代治疗后均出现生长加速，改善了他们的生长预后。现在，一组新的16例CDGA患者接受了1至3年的hGH治疗。在第一年观察到追赶生长，到第三年降至正常生长速度。这种正常生长速度仍比治疗前速度快。尽管hGH治疗可能对CDGA有效，但仅在因身材矮小引起心理问题的病例中才合理。
