School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, P.R. China.
Nanoscale. 2020 Oct 14;12(38):19516-19535. doi: 10.1039/d0nr05746k. Epub 2020 Sep 23.
Graphene and graphene-like two-dimensional (2D) nanomaterials, such as black phosphorus (BP), transition metal carbides/carbonitrides (MXene) and transition metal dichalcogenides (TMD), have been extensively studied in recent years due to their unique physical and chemical properties. With atomic-scale thickness, these 2D materials and their derivatives can react with ROS and even scavenge ROS in the dark. With excellent biocompatibility and biosafety, they show great application potential in the antioxidant field and ROS detection for diagnosis. They can also generate ROS under light and be applied in antibacterial, photodynamic therapy (PDT), and other biomedical fields. Understanding the degradation mechanism of 2D nanomaterials by ROS generated under ambient conditions is crucial to developing air stable devices and expanding their application ranges. In this review, we summarize recent advances in 2D materials with a focus on the relationship between their intrinsic structure and the ROS scavenging or generating ability. We have also highlighted important guidelines for the design and synthesis of highly efficient ROS scavenging or generating 2D materials along with their biomedical applications.
近年来，由于具有独特的物理和化学性质，石墨烯和类石墨烯二维（2D）纳米材料，如黑磷（BP）、过渡金属碳化物/氮化物（MXene）和过渡金属二卤代物（TMD），受到了广泛的研究。这些 2D 材料及其衍生物的原子级厚度可以与 ROS 反应，甚至可以在黑暗中清除 ROS。由于具有优异的生物相容性和生物安全性，它们在抗氧化领域和用于诊断的 ROS 检测方面显示出巨大的应用潜力。它们还可以在光下产生 ROS，并应用于抗菌、光动力疗法（PDT）和其他生物医学领域。了解在环境条件下生成的 ROS 对 2D 纳米材料的降解机制，对于开发空气稳定的器件和扩大其应用范围至关重要。在这篇综述中，我们总结了 2D 材料的最新进展，重点关注它们的内在结构与清除或产生 ROS 的能力之间的关系。我们还强调了设计和合成高效清除或产生 ROS 的 2D 材料的重要指导原则，以及它们在生物医学中的应用。
