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无柄塑料闪烁探测器的制造与特性研究

Fabrication and characterization of a stemless plastic scintillation detector.

作者信息

Hupman Michael A, Monajemi Thalat, Valitova Irina, Hill Ian G, Syme Alasdair

机构信息

Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada.

Department of Radiation Oncology, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada.

出版信息

Med Phys. 2020 Nov;47(11):5882-5889. doi: 10.1002/mp.14475. Epub 2020 Oct 6.

Abstract

PURPOSE

To fabricate a stemless plastic scintillation detector (SPSD) and characterize its linearity and reproducibility, and its dependence on energy and dose per pulse; and to apply it to clinical PDD and output factor measurements.

METHODS

An organic bulk heterojunction photodiode was fabricated by spin coating a blend of P3HT and PCBM onto an ITO-coated glass substrate and depositing aluminum top contacts. Eljen scintillators (5 × 5 × 5 mm ; EJ-204, EJ-208, and EJ-260) or Saint-Gobain scintillators (3 × 3 × 2 mm ; BC-400 and BC-412) were placed on the opposite side of the glass using a silicone grease (optical coupling agent) creating the SPSD. Energy dependence was measured by using 100, 180, and 300 kVp photon beams from an orthovoltage treatment unit (Xstrahl 300) and 6 and 10 MV photons from a Varian TrueBeam linear accelerator. Linearity, dose per pulse dependence, output factors, and PDDs were measured using a 6 MV photon beam. PDDs and output factors were compared to ion chamber measurements. A control device was fabricated by substituting polystyrene (PS) for the P3HT/PCBM layer. No photocurrent should be generated in the control device and so any current measured is due to Compton current in the electrodes, wires, and surroundings from the irradiation. Output factors were corrected by subtracting the signal measured using the control device from the photodiode measured signal to yield the photocurrent.

RESULTS

Each SPSD had excellent linearity with dose having an r of 1 and sensitivities of 1.07 nC/cGy, 1.04 nC/cGy, 1.00 nC/cGy and 0.10 nC/cGy, and 0.10 nC/cGy for EJ-204, EJ-208, EJ-260 (5 × 5 × 5 mm volumes), BC-400, and BC-412 (3 × 3 × 2 mm volumes), respectively. No significant dose per pulse dependence was measured. Output factors matched within 1% for the large scintillators for field sizes of 5 × 5 cm to 25 × 25 cm , but there was a large under-response at field sizes below 3 × 3 cm . After correcting the signal of the small scintillators by subtracting the current measured using the PS control, the output factors agreed with the ion chamber measurements within 1% from field sizes 1 × 1 cm to 20 × 20 cm . The impact of Cerenkov emissions in the scintillator was effectively corrected with a simple reflective coating on the scintillator. In comparison to a 6 MV photon beam, the large scintillator SPSDs exhibited 37%, 52%, and 73% of the response at energies 100 kVp, 180 kVp and 300 kVp, respectively.

CONCLUSION

The principle of the SPSD was demonstrated. Devices had excellent linearity, reproducibility, and no significant dose per pulse dependence, and a simple reflective coating was sufficient to correct for Cerenkov emissions from within the scintillator. The devices demonstrated similar energy dependence to other scintillator detectors used in a radiotherapy setting.

摘要

目的

制造一种无柄塑料闪烁探测器(SPSD),并对其线性、再现性及其对能量和每脉冲剂量的依赖性进行表征;并将其应用于临床百分深度剂量(PDD)和输出因子测量。

方法

通过将聚(3-己基噻吩)(P3HT)和富勒烯衍生物(PCBM)的混合物旋涂到涂有氧化铟锡(ITO)的玻璃基板上并沉积铝顶接触来制造有机本体异质结光电二极管。使用硅脂(光学耦合剂)将Eljen闪烁体(5×5×5 mm;EJ-204、EJ-208和EJ-260)或圣戈班闪烁体(3×3×2 mm;BC-400和BC-412)放置在玻璃的另一侧,从而制造出SPSD。使用来自正交电压治疗单元(Xstrahl 300)的100、180和300 kVp光子束以及来自瓦里安TrueBeam直线加速器的6和10 MV光子测量能量依赖性。使用6 MV光子束测量线性、每脉冲剂量依赖性、输出因子和PDD。将PDD和输出因子与电离室测量结果进行比较。通过用聚苯乙烯(PS)代替P3HT/PCBM层来制造对照装置。对照装置中不应产生光电流,因此测量到的任何电流都是由于照射在电极、电线和周围环境中产生的康普顿电流。通过从光电二极管测量信号中减去使用对照装置测量的信号来校正输出因子,以产生光电流。

结果

每个SPSD与剂量具有出色的线性关系,相关系数r为1,EJ-204、EJ-208、EJ-260(5×5×5 mm体积)、BC-400和BC-412(3×3×2 mm体积)的灵敏度分别为1.07 nC/cGy、1.04 nC/cGy、1.00 nC/cGy、0.10 nC/cGy和0.10 nC/cGy。未测量到明显的每脉冲剂量依赖性。对于5×5 cm至25×25 cm射野尺寸的大尺寸闪烁体,输出因子在1%以内匹配,但在低于3×3 cm的射野尺寸下存在较大的响应不足。通过减去使用PS对照测量的电流来校正小尺寸闪烁体的信号后,对于1×1 cm至20×20 cm的射野尺寸,输出因子与电离室测量结果在1%以内一致。通过在闪烁体上进行简单的反射涂层有效地校正了闪烁体中切伦科夫辐射的影响。与6 MV光子束相比,大尺寸闪烁体SPSD在100 kVp、180 kVp和300 kVp能量下的响应分别为37%、52%和73%。

结论

证明了SPSD的原理。该装置具有出色的线性、再现性,且每脉冲剂量依赖性不明显,并通过简单的反射涂层足以校正闪烁体内的切伦科夫辐射。该装置表现出与放射治疗中使用的其他闪烁探测器类似的能量依赖性。

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