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用于小视野辐照高能 X 射线束的高空间分辨率无机闪烁体探测器。

High spatial resolution inorganic scintillator detector for high-energy X-ray beam at small field irradiation.

机构信息

Aix Marseille Université, CNRS, CINaM, UMR 7325, 13288, Marseille, France.

Institut Paoli-Calmettes, 13009, Marseille, France.

出版信息

Med Phys. 2020 Mar;47(3):1364-1371. doi: 10.1002/mp.14002. Epub 2020 Jan 23.

Abstract

PURPOSE

Small field dosimetry for radiotherapy is one of the major challenges due to the size of most dosimeters, for example, sufficient spatial resolution, accurate dose distribution and energy dependency of the detector. In this context, the purpose of this research is to develop a small size scintillating detector targeting small field dosimetry and compare its performance with other commercial detectors.

METHOD

An inorganic scintillator detector (ISD) of about 200 µm outer diameter was developed and tested through different small field dosimetric characterizations under high-energy photons (6 and 15 MV) delivered by an Elekta Linear Accelerator (LINAC). Percentage depth dose (PDD) and beam profile measurements were compared using dosimeters from PTW namely, microdiamond and PinPoint three-dimensional (PP3D) detector. A background fiber method has been considered to quantitate and eliminate the minimal Cerenkov effect from the total optical signal magnitude. Measurements were performed inside a water phantom under IAEA Technical Reports Series recommendations (IAEA TRS 381 and TRS 483).

RESULTS

Small fields ranging from 3 × 3 cm , down to 0.5 × 0.5 cm were sequentially measured using the ISD and commercial dosimeters, and a good agreement was obtained among all measurements. The result also shows that, scintillating detector has good repeatability and reproducibility of the output signal with maximum deviation of 0.26% and 0.5% respectively. The Full Width Half Maximum (FWHM) was measured 0.55 cm for the smallest available square size field of 0.5 × 0.5 cm , where the discrepancy of 0.05 cm is due to the scattering effects inside the water and convolution effect between field and detector geometries. Percentage depth dose factor dependence variation with water depth exhibits nearly the same behavior for all tested detectors. The ISD allows to perform dose measurements at a very high accuracy from low (50 cGy/min) to high dose rates (800 cGy/min) and was found to be independent of dose rate variation. The detection system also showed an excellent linearity with dose; hence, calibration was easily achieved.

CONCLUSIONS

The developed detector can be used to accurately measure the delivered dose at small fields during the treatment of small volume tumors. The author's measurement shows that despite using a nonwater-equivalent detector, the detector can be a powerful candidate for beam characterization and quality assurance in, for example, radiosurgery, Intensity-Modulated Radiotherapy (IMRT), and brachytherapy. Our detector can provide real-time dose measurement and good spatial resolution with immediate readout, simplicity, flexibility, and robustness.

摘要

目的

由于大多数剂量计的尺寸较小,例如足够的空间分辨率、准确的剂量分布和探测器的能量依赖性,因此放射治疗的小射野剂量测定是主要挑战之一。在这种情况下,本研究的目的是开发一种针对小射野剂量测定的小尺寸闪烁探测器,并将其性能与其他商业探测器进行比较。

方法

开发了一种外径约为 200µm 的无机闪烁体探测器(ISD),并通过高能光子(6 和 15MV)下的不同小射野剂量特性进行了测试,这些光子由 Elekta 直线加速器(LINAC)提供。使用来自 PTW 的微金刚石和 PinPoint 三维(PP3D)探测器分别进行百分深度剂量(PDD)和射束轮廓测量。考虑了背景纤维方法,以量化并消除总光学信号幅度中的最小切伦科夫效应。在 IAEA 技术报告系列建议(IAEA TRS 381 和 TRS 483)下,在水模体内进行了测量。

结果

使用 ISD 和商业剂量计依次测量了从 3×3cm 到 0.5×0.5cm 的小射野,所有测量结果均吻合良好。结果还表明,闪烁探测器的输出信号具有良好的重复性和再现性,最大偏差分别为 0.26%和 0.5%。对于最小的可用正方形尺寸为 0.5×0.5cm 的射野,全宽半高(FWHM)测量为 0.55cm,其中 0.05cm 的差异是由于水内的散射效应和射野与探测器几何形状之间的卷积效应所致。所有测试探测器的水深度与深度剂量因子依赖性变化均表现出相似的行为。ISD 允许在非常高的精度下进行剂量测量,从低(50cGy/min)到高剂量率(800cGy/min),并且发现其与剂量率变化无关。检测系统也表现出良好的剂量线性度,因此易于实现校准。

结论

所开发的探测器可用于在治疗小体积肿瘤时准确测量小射野中的传递剂量。作者的测量结果表明,尽管使用了非水等效探测器,但该探测器可以成为例如放射外科、强度调制放射疗法(IMRT)和近距离放射疗法中的束特性和质量保证的有力候选者。我们的探测器可以提供实时剂量测量和良好的空间分辨率,具有即时读数、简单性、灵活性和坚固性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e682/7155062/47e16bd7c8db/MP-47-1364-g001.jpg

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