Guangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China.
Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural Small Molecule Drugs, Engineering Laboratory of Shenzhen Natural Small Molecule Innovative Drugs, Shenzhen University Health Science Center, Shenzhen 518060, China.
Viruses. 2020 Sep 21;12(9):1051. doi: 10.3390/v12091051.
As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism. Although immune checkpoint therapy has been successfully used in cancer treatment, numerous studies have suggested that such therapy may also be highly relevant for treating viral infection, especially chronic viral infections. However, it has not yet been applied in this manner. Here, we reviewed recent findings regarding immune checkpoints in viral infections, including COVID-19, and discussed the role of immune checkpoints in different viral infections, as well as the potential for applying immune checkpoint blockades as antiviral therapy.
随着越来越多的证据表明病毒感染细胞（如癌细胞）通过免疫检查点负调控 T 细胞的功能，人们越来越清楚地认识到病毒感染同样利用免疫检查点作为免疫系统逃避机制。尽管免疫检查点疗法已成功用于癌症治疗，但许多研究表明，这种疗法可能也与治疗病毒感染高度相关，尤其是慢性病毒感染。然而，目前尚未以这种方式应用。在这里，我们回顾了最近关于病毒感染（包括 COVID-19）中免疫检查点的研究结果，并讨论了免疫检查点在不同病毒感染中的作用，以及将免疫检查点阻断作为抗病毒治疗的潜力。
