Bharat Biotech Foundation, Genome Valley, Turkapally, Shameerpet Mandal, Hyderabad 500078, India.
Immunotherapy. 2009 Jul;1(4):691-711. doi: 10.2217/imt.09.26.
Among the microorganisms that cause diseases of medical or veterinary importance, the only group that is entirely dependent on the host, and hence not easily amenable to therapy via pharmaceuticals, is the viruses. Since viruses are obligate intracellular pathogens, and therefore depend a great deal on cellular processes, direct therapy of viral infections is difficult. Thus, modifying or targeting nonspecific or specific immune responses is an important aspect of intervention of ongoing viral infections. However, as a result of the unavailability of effective vaccines and the extended duration of manifestation, chronic viral infections are the most suitable for immunotherapies. We present an overview of various immunological strategies that have been applied for treating viral infections after exposure to the infectious agent.
在引起医学或兽医重要疾病的微生物中，唯一完全依赖宿主的微生物组，因此不易通过药物治疗，是病毒。由于病毒是专性细胞内病原体，因此非常依赖细胞过程，因此直接治疗病毒感染是困难的。因此，修饰或靶向非特异性或特异性免疫反应是干预正在进行的病毒感染的一个重要方面。然而，由于缺乏有效的疫苗和表现时间延长，慢性病毒感染最适合免疫治疗。我们介绍了在暴露于感染因子后，用于治疗病毒感染的各种免疫策略的概述。
