Nieminen M S, Toivonen L, Manninen V, Frick H
Am J Cardiol. 1987 Jun 15;59(16):27H-32H. doi: 10.1016/0002-9149(87)90141-x.
The acute hemodynamic effects of pirmenol and lidocaine were studied in a double-blind, placebo-controlled investigation. Thirty patients undergoing catheterization received one of the following: pirmenol as a 50-mg intravenous bolus injection followed by a 2.5 mg/min infusion, lidocaine as a 75-mg intravenous bolus injection followed by a 3 mg/min infusion or placebo administered in a similar fashion. Mean plasma pirmenol concentrations during steady infusion were 2.3 to 2.4 mg/liter, and mean plasma lidocaine concentrations were 16 to 24 mumol/liter. Pirmenol increased heart rate from baseline by 10 beats/min (p less than 0.001) and mean arterial pressure by 5 mm Hg (p less than 0.001), with similar increases in systemic (p less than 0.05) and pulmonary vascular resistance (p less than 0.01). Lidocaine induced a comparable increase in mean arterial pressure (6 mm Hg, p less than 0.001), but unlike pirmenol, it increased left ventricular and diastolic pressure by 2.8 mm Hg (p less than 0.05). Indexes of left ventricular work were not affected by either drug. Echocardiographic ejection fraction was reduced more by pirmenol (-0.05, p less than 0.0001) than by lidocaine (-0.03, p less than 0.05), a difference that may be related to the changes in heart rate. Side effects were not observed in any patient. The myocardial depressant effect of pirmenol is relatively slight and comparable to that of lidocaine.
在一项双盲、安慰剂对照研究中，对吡美诺和利多卡因的急性血流动力学效应进行了研究。30名接受导管插入术的患者接受了以下治疗之一：静脉推注50毫克吡美诺，随后以2.5毫克/分钟的速度输注；静脉推注75毫克利多卡因，随后以3毫克/分钟的速度输注；或以类似方式给予安慰剂。持续输注期间，血浆吡美诺平均浓度为2.3至2.4毫克/升，血浆利多卡因平均浓度为16至24微摩尔/升。吡美诺使心率较基线增加10次/分钟（p<0.001），平均动脉压增加5毫米汞柱（p<0.001），全身血管阻力（p<0.05）和肺血管阻力也有类似增加（p<0.01）。利多卡因使平均动脉压有类似的升高（6毫米汞柱，p<0.001），但与吡美诺不同的是，它使左心室和舒张压升高2.8毫米汞柱（p<0.05）。两种药物均未影响左心室作功指标。与利多卡因（-0.03，p<0.05）相比，吡美诺使超声心动图射血分数降低更多（-0.05，p<0.0001），这种差异可能与心率变化有关。未在任何患者中观察到副作用。吡美诺的心肌抑制作用相对较轻，与利多卡因相当。
