Garin E H
Am J Dis Child. 1987 Jul;141(7):769-71. doi: 10.1001/archpedi.1987.04460070071028.
The metolazone-furosemide combination of diuretics was compared with the thiazide-furosemide combination in nephrotic patients with edema. Nine patients underwent a crossover, randomized study receiving furosemide (2 mg/kg per dose) and either metolazone (dose varied according to weight) or chlorothiazide (10 mg/kg per dose). An additive natriuretic and diuretic effect was observed after both metolazone and thiazide were combined with furosemide. The use of both types of diuretic combination was associated with marked kaliuresis. These combinations of diuretics seem equally effective in inducing natriuresis and diuresis in edematous nephrotic patients.
在患有水肿的肾病患者中，将美托拉宗 - 呋塞米联合利尿剂与噻嗪类 - 呋塞米联合利尿剂进行了比较。9名患者进行了交叉随机研究，接受呋塞米（每剂2mg/kg）以及美托拉宗（剂量根据体重变化）或氢氯噻嗪（每剂10mg/kg）。美托拉宗和噻嗪类与呋塞米联合使用后均观察到了相加的利钠和利尿作用。两种类型的利尿剂联合使用均伴有明显的尿钾增多。这些利尿剂组合在诱导水肿性肾病患者利钠和利尿方面似乎同样有效。
