methylation is associated with hematologic improvement in low-risk myelodysplastic syndrome patients treated with Pai-Neng-Da.

OBJECTIVE

The aim of this prospective randomized controlled clinical trial was to explore the relationship between methylation and Pai-Neng-Da (PND) in the treatment of patients with low-risk myelodysplastic syndrome (MDS).

METHODS

There were 82 low-risk MDS patients who were randomly divided into the following two groups: androl, thalidomide, and PND capsule (ATP group, n = 41); or androl and thalidomide (AT group, n = 41). Hemoglobin and neutrophil and platelet counts and changes in methylation level were assessed.

RESULTS

The plasma hemoglobin level increased in both groups after treatment. However, the platelet count increased only in the ATP group. Patients in the ATP group had a better platelet response than the AT group, and methylation markedly decreased after treatment with ATP but not after treatment with AT. Moreover, male patients had a significantly lower methylation level than female patients, while platelet counts from male patients increased dramatically after the ATP regimens compared with female patients. methylation changes were negatively correlated with platelet changes in ATP group.

CONCLUSION

PND can improve hematological parameters and decrease the methylation level. Decreasing methylation is associated with the hematologic response that includes platelet in methylation. http://www.chictr.org.cn/: ChiCTR-IOR-15006635.