Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, Germany.
Social and Preventive Medicine, University of Potsdam, Am Neuen Palais 10, 14469Potsdam, Germany.
Acta Neuropsychiatr. 2021 Feb;33(1):22-30. doi: 10.1017/neu.2020.31. Epub 2020 Sep 24.
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF).
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment.
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS.
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
抑郁和冠心病（CHD）是高度共病的。脑源性神经营养因子（BDNF）在心血管过程中起着重要作用。抑郁患者通常表现出 BDNF 浓度降低。我们分析了 CHD 患者样本中 BDNF 与抑郁之间的关系，并进一步区分了认知情感和躯体抑郁症状。我们还调查了 BDNF 是否与躯体合并症负担、急性冠状动脉综合征（ACS）或充血性心力衰竭（CHF）相关。
我们评估了 225 名住院 CHD 患者的以下变量：BDNF 浓度、抑郁[患者健康问卷-9（PHQ-9）]、躯体合并症（Charlson 合并症指数）、CHF、ACS、血小板计数、吸烟状况和抗抑郁治疗。
回归模型显示，BDNF 与抑郁严重程度无关。尽管抑郁患者（PHQ-9 评分>7）的 BDNF 浓度明显低于非抑郁患者（p=0.04），但在控制混杂因素后，这并不具有统计学意义（p=0.15）。认知情感症状和躯体合并症负担均与 BDNF 浓度密切相关，但未达到统计学意义（p=0.08，p=0.06）。CHF 患者的 BDNF 减少（p=0.02）。BDNF 与 ACS 之间无协变量调整的显著相关性。
血清 BDNF 浓度与心血管功能障碍有关。在研究抑郁与 BDNF 之间的关系时，应考虑躯体合并症。
