微卫星不稳定驱动的转移性甲状旁腺癌，采用抗 PD-1 免疫疗法，即 pembrolizumab 治疗。
Microsatellite instability driven metastatic parathyroid carcinoma managed with the anti-PD1 immunotherapy, pembrolizumab.
机构信息
Internal Medicine, Touro University California, Vallejo, California, USA
Internal Medicine, Touro University California, Vallejo, California, USA.
出版信息
BMJ Case Rep. 2020 Sep 23;13(9):e235293. doi: 10.1136/bcr-2020-235293.
Abstract
The present case report describes a 65-year-old man with Lynch syndrome and hypercalcaemia associated with hyperparathyroidism. Parathyroid surgery confirmed the diagnosis of parathyroid carcinoma. Serum calcium and parathyroid hormone (PTH) concentrations serially increased after initial surgery. Imaging study and subsequent biopsy confirmed lung metastases with mismatch repair deficiency. Pembrolizumab was initiated achieving 60% reduction in tumour burden.
摘要
本病例报告描述了一例患有林奇综合征和高钙血症相关甲状旁腺功能亢进的 65 岁男性。甲状旁腺癌的诊断经甲状旁腺手术得到确认。初次手术后，血清钙和甲状旁腺激素（PTH）浓度连续升高。影像学研究和随后的活检证实存在错配修复缺陷的肺转移。帕博利珠单抗治疗后肿瘤负荷减少了 60%。
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