Department of Surgery, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190, Belo Horizonte, 30130-100, Brazil.
Section on Genetics and Endocrinology (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, USA.
Endocrine. 2020 Jan;67(1):204-208. doi: 10.1007/s12020-019-02136-z. Epub 2019 Nov 28.
Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered.
A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery.
Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.
甲状旁腺癌是一种罕见的肿瘤,预后不良,尤其是发生转移时。虽然化疗和/或放疗对转移性疾病没有临床价值,但应考虑免疫治疗。
一名患有 CDC73 相关转移性甲状旁腺癌的患者接受了抗 hPTH 免疫治疗联合手术治疗。
在接受五轮抗 hPTH 免疫治疗和随后的手术治疗后,报告了一例 12 年的转移性甲状旁腺癌缓解。该病例进一步支持了免疫治疗可能使更多类型的癌症受益的不断扩大的范围。