Jaffe N
Am J Pediatr Hematol Oncol. 1987 Spring;9(1):62-7. doi: 10.1097/00043426-198721000-00011.
Advances in the treatment of childhood cancer have produced dramatic changes in survival. Unfortunately, many of the advances associated with this improvement have been accompanied by delayed sequelae induced by treatments such as surgery, radiotherapy, and chemotherapy. This article reviews published reports of treatment sequelae and examines their impact on the design of current forms of treatment. Recognition of the delayed effects of these treatment modalities has resulted in alterations in established therapies. This alteration is an ongoing process and demonstrates the concern of physicians with improving quality of life for long-term survivors of childhood cancer.
儿童癌症治疗方面的进展已使生存率发生了显著变化。不幸的是，与这种改善相关的许多进展都伴随着手术、放疗和化疗等治疗手段引发的迟发性后遗症。本文回顾了已发表的关于治疗后遗症的报告，并探讨了它们对当前治疗形式设计的影响。对这些治疗方式迟发性影响的认识已导致既定疗法的改变。这种改变是一个持续的过程，体现了医生对提高儿童癌症长期幸存者生活质量的关注。
