Goldman S, Johnson F L
Department of Pediatrics, University of Chicago Medical Center, Illinois.
Endocrinol Metab Clin North Am. 1993 Sep;22(3):617-29.
As the survival of children with cancer improves, attention must now be focused on understanding and preventing long-term toxicities of treatment and improving the quality of survival. Gonadal toxicity is relatively common, particularly with radiation therapy and alkylating agents. Continued research into the pathogenesis and prevention of gonadal toxicities needs to be included in future treatment strategies for childhood cancer. This will require a multidisciplinary approach with input from pediatric hematologist/oncologists, radiation oncologists, and pediatric endocrinologists.
随着癌症患儿生存率的提高，现在必须将注意力集中在了解和预防治疗的长期毒性以及提高生存质量上。性腺毒性相对常见，尤其是在放射治疗和使用烷化剂时。对性腺毒性的发病机制和预防的持续研究需要纳入未来儿童癌症的治疗策略中。这将需要儿科血液科医生/肿瘤学家、放射肿瘤学家和儿科内分泌学家的多学科方法。
