Ojha Niranjan, Riaz Sana, Eranki Ambika
Internal Medicine, State University of New York Upstate Medical University, Syracuse, USA.
Infectious Disease, State University of New York Upstate Medical University, Syracuse, USA.
Cureus. 2020 Aug 21;12(8):e9911. doi: 10.7759/cureus.9911.
Neurotoxicity is a rare side effect of Cefepime use. Cefepime can cross the blood-brain barrier and can be neurotoxic by competitive albeit weak antagonism of the gamma-aminobutyric acid complex. It is cleared by the kidneys which puts individuals with renal impairment at risk of side effects. We describe a case of Cefepime neurotoxicity in the context of nephrotoxicity secondary to the use of other drugs.
神经毒性是使用头孢吡肟罕见的副作用。头孢吡肟可穿过血脑屏障，通过对γ-氨基丁酸复合物的竞争性（尽管较弱）拮抗作用而具有神经毒性。它经肾脏清除，这使肾功能不全的个体有出现副作用的风险。我们描述了一例在因使用其他药物继发肾毒性背景下发生的头孢吡肟神经毒性病例。
