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免疫功能正常患者出现呈簇状颅内结核瘤的中枢神经系统结核

Central Nervous System Tuberculosis With Shower Like Pattern of Intracranial Tuberculomas in an Immunocompetent Patient.

作者信息

Arif Saeed, Arif Shaheer, Slehria Atiq-Ur-Rehman, Yousaf Ghulam, Nawaz Khurram Haq

机构信息

Neurology, Pak-Emirates Military Hospital, Rawalpindi, PAK.

Radiology, Armed Forces Insititute of Radiology and Imaging, Rawalpindi, PAK.

出版信息

Cureus. 2020 Aug 21;12(8):e9922. doi: 10.7759/cureus.9922.

Abstract

Central nervous system tuberculosis (CNS TB), though comparatively uncommon as compared to other forms of extrapulmonary tuberculosis (TB), results in high morbidity and mortality. The symptoms are non-specific and of a progressive nature resulting in delayed diagnosis. We present a case of CNS TB that presented two months after the onset of symptoms. The patient's condition reached the point of being bedbound. On investigation, the widespread involvement of the brain with shower-like pattern of ring enhancing tuberculomas and associated tuberculous meningitis was found. This was a surprising finding considering the patient was immunocompetent. Contrast-enhanced magnetic resonance imaging showed lesions in midbrain, pons, medulla, thalamus, bilateral cerebellar hemispheres and bilateral cerebral hemispheres. Upon treatment initiation the patient responded well with resolution of all lesions.

摘要

中枢神经系统结核(CNS TB)虽然与其他肺外结核(TB)形式相比相对少见,但会导致高发病率和死亡率。其症状不具特异性且呈进行性,导致诊断延迟。我们报告一例中枢神经系统结核病例,该病例在症状出现两个月后才就诊。患者病情发展到卧床不起的程度。经检查,发现脑部广泛受累,有呈簇状分布的环形强化结核瘤以及相关的结核性脑膜炎。考虑到患者免疫功能正常,这一发现令人惊讶。对比增强磁共振成像显示中脑、脑桥、延髓、丘脑、双侧小脑半球和双侧大脑半球均有病变。开始治疗后,患者对治疗反应良好,所有病变均消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/102f/7505619/06aff3508f48/cureus-0012-00000009922-i01.jpg

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