Nomogram developed with selenoprotein S (SelS) genetic variation and clinical characteristics predicting risk of coronary artery disease in a Chinese population.

BACKGROUND

Selenoprotein S (SelS) is a novel selenoprotein encoded by the gene on chromosome 15q26.3. SelS is associated with the development of diabetes, dyslipidemia and macrovascular complications. However, the relationship between genetic polymorphisms of SelS and coronary artery disease (CAD) remains unclear.

METHODS

In the present study, we genotyped four single nucleotide polymorphisms (rs117613208, rs117512970, rs986500879, rs542989868) of gene using direct sequencing method in a case-control study (576 CAD cases and 452 control subjects). Furthermore, we developed a predictive model using SelS genetic variation and clinical variables to predict risk of CAD.

RESULTS

We found that rs117613208 T allele was more frequent in the CAD cases than that in the controls. Logistic regression analysis suggested after adjustment of other confounders, the difference remained significant between the two groups [odds ratio (OR) =2.107, 95% confidence interval (CI): 1.239-3.583, P<0.006]. Using SelS rs117613208 T allele, age, smoking, diabetes, hypertension, apolipoprotein A1 (apoA1), and lipoprotein A [Lp(a)] (GASDLY score), we developed a diagnostic model of CAD (AUC: 0.806, 95% CI: 0.776-0.836, P<0.001, sensitivity: 74.7%, specificity:75.5%).

CONCLUSIONS

The present study suggested that genetic polymorphism of SelS was independent associated with CAD and GASDLY score may be a novel diagnostic model for CAD in a Chinese population.