Institute of Analytical and Bioanalytical Chemistry, Ulm University Albert-Einstein-Allee 11, 89081 Ulm, Germany.
J Breath Res. 2020 Sep 24;14(4):043001. doi: 10.1088/1752-7163/abaf07.
Cavity-enhanced absorption spectroscopies (CEAS) have gained importance in a wide range of applications in molecular spectroscopy. The development of optical sensors based on the CEAS techniques coupled with the continuous wave or pulsed laser sources operating in the mid-infrared or near-infrared spectral regime uniquely offers molecularly selective and ultra-sensitive detection of trace species in complex matrices including exhaled human breath. In this review, we discussed recent applications of CEAS for analyzing trace constituents within the exhaled breath matrix facilitating the non-invasive assessment of human health status. Next to a brief discussion on the mechanisms of formation of trace components found in the exhaled breath matrix related to particular disease states, existing challenges in CEAS and future development towards non-invasive clinical diagnostics will be discussed.
腔增强吸收光谱学 (CEAS) 在分子光谱学的广泛应用中变得越来越重要。基于 CEAS 技术与连续波或脉冲激光源相结合的光学传感器的发展，在中红外或近红外光谱范围内，独特地提供了对复杂基质中痕量物质的分子选择性和超灵敏检测，包括呼出的人体呼吸。在这篇综述中，我们讨论了 CEAS 在分析呼出呼吸基质中痕量成分方面的最新应用，有助于无创评估人体健康状况。除了简要讨论与特定疾病状态相关的呼出呼吸基质中痕量成分形成的机制外，还将讨论 CEAS 中存在的挑战以及朝着无创临床诊断的未来发展。
