Pera M, Cardesa A, Pera C, Mohr U
Anticancer Res. 1987 May-Jun;7(3 Pt A):301-8.
The role of diet in carcinogenesis has received much attention in recent years. The incidence of oesophageal cancer varies widely in different geographical regions and oesophageal cancer shows one of the greatest correlations between the diet type and eventual malignant development. Oesophageal carcinogenesis involves the combined action of predispositional, initiatory, and promotional factors. Specific dietary deficiencies (vitamins and minerals) may create a sensitized "environment" for the combined activities of initiatory and promotional factors. Other predispositional factors include physical abrasion (irritant vegetal components, thermal injury) and chemical injuries (alcohol, tobacco). Initiatory factors such as nitrosamines or their precursors in the diet are also considered.
近年来，饮食在致癌过程中的作用备受关注。食管癌的发病率在不同地理区域差异很大，并且食管癌在饮食类型与最终恶性发展之间呈现出最为显著的关联之一。食管癌的发生涉及易患因素、起始因素和促进因素的共同作用。特定的饮食缺乏（维生素和矿物质）可能为起始因素和促进因素的联合作用创造一个敏感的“环境”。其他易患因素包括物理磨损（刺激性植物成分、热损伤）和化学损伤（酒精、烟草）。饮食中的亚硝胺或其前体等起始因素也被考虑在内。
