Kozłowska K, Zurawska-Czupa B, Kostulak A
Arch Immunol Ther Exp (Warsz). 1986;34(5-6):595-605.
The reactivity of sera of hamsters bearing melanotic and amelanotic melanoma with isolated melanocytes was evaluated using immunoadherence test and cross-reactions. Besides, the ability of neoplastic melanocytes to absorption of antibodies from these sera, was tested. The reactivity of cells of both melanomas with serum of hamsters bearing the original type--melanotic melanoma--appeared the same and twice as high in amelanotic cells with serum of animals bearing amelanotic melanoma. This suggests that in the course of spontaneous alteration, the new form--amelanotic, does not lose the original antigens but acquires new ones, not present on the melanotic cells. The above findings were confirmed by the absorption test.
使用免疫黏附试验和交叉反应评估了携带黑素瘤和无黑素黑素瘤的仓鼠血清与分离黑素细胞的反应性。此外，还测试了肿瘤性黑素细胞从这些血清中吸收抗体的能力。两种黑素瘤细胞与携带原始类型（黑素瘤）的仓鼠血清的反应性相同，而无黑素细胞与携带无黑素黑素瘤的动物血清的反应性则高出两倍。这表明在自发改变过程中，新的形式（无黑素的）不会失去原始抗原，而是获得了黑素细胞上不存在的新抗原。吸收试验证实了上述发现。
