Rand J H, Badimon L, Gordon R E, Uson R R, Fuster V
Arteriosclerosis. 1987 May-Jun;7(3):287-91. doi: 10.1161/01.atv.7.3.287.
The von Willebrand factor (vWF) has been generally accepted as a marker for endothelial cells. In a systematic immunolocalization study of porcine blood vessels that used indirect immunofluorescence with a monospecific polyclonal anti-vWF and two monoclonal anti-vWFs, we observed that vWF is not universally distributed in intact, fresh endothelia. vWF is consistently localized in veins, with the exception of the pulmonic vein. In arteries, vWF is generally absent except for areas of the distal abdominal aorta, the vaso vasorum of the thoracic aorta, and the pulmonic artery. We conclude that there are regional differences in the distribution of vWF in the various endothelial beds of pigs.
血管性血友病因子（vWF）已被普遍认为是内皮细胞的标志物。在一项对猪血管进行的系统免疫定位研究中，我们使用单特异性多克隆抗vWF和两种单克隆抗vWF进行间接免疫荧光检测，观察到vWF并非普遍分布于完整的新鲜内皮中。vWF始终定位于静脉中，但肺静脉除外。在动脉中，除了腹主动脉远端区域、胸主动脉的滋养血管和肺动脉外，vWF通常不存在。我们得出结论，猪不同内皮床中vWF的分布存在区域差异。
