J Biomed Nanotechnol. 2020 Apr 1;16(4):481-491. doi: 10.1166/jbn.2020.2908.
There is continued interest in Nano Carbon Materials (NCMs) and two of these, Fullerene C and Graphene have received Nobel prizes. Low solubility in most solvents has been a stumbling block in their industrial use. We report here the successful synthesis of a new water soluble tri-adduct of Fullerene C using a two-step procedure to obtain the water soluble s-Tri-(1-aziridino-2, 3-dimethoxy-benzene-5-carboxylato-6-carboxylic acid)-H-Fullerene C-Manganese (II) Complex ( III ). Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS) and Electron Paramagnetic Resonance (EPR) studies critically helped recognize the presence of an atom of Manganese in the complex. The new complex was also characterized by Ultra violet-Visible (UV-Vis.). Fourier Transform-Infra Red (FT-IR) spectroscopy, Energy Dispersive X-ray analysis (EDAX), Scanning Electron Microscopy (SEM), Thermal Gravimetric Analysis (TGA), and powder X-ray diffraction. The new compound has been shown to possess anti-cancer activity comparable to Doxorubicin, currently the most used anti-cancer drug. This new water soluble Fullerene C-Manganese (II) tri-adduct complex ( III ) thus holds much promise for the fields of biology, biochemistry, medicine, and materials science.
人们对纳米碳材料（NCMs）持续感兴趣，其中富勒烯 C 和石墨烯已获得诺贝尔奖。在大多数溶剂中的低溶解度一直是其工业应用的绊脚石。我们在这里报告了使用两步法成功合成了一种新的水溶性富勒烯 C 的三加合物，以获得水溶性 s-三-（1-氮丙啶-2,3-二甲氧基-苯-5-羧酸酯-6-羧酸）-H-富勒烯 C-锰（II）配合物（III）。基质辅助激光解吸电离质谱（MALDI-MS）和电子顺磁共振（EPR）研究有助于确定配合物中存在一个锰原子。新的配合物还通过紫外可见（UV-Vis）进行了表征。傅里叶变换-红外（FT-IR）光谱、能量色散 X 射线分析（EDAX）、扫描电子显微镜（SEM）、热重分析（TGA）和粉末 X 射线衍射。该新化合物已被证明具有与阿霉素相当的抗癌活性，阿霉素是目前使用最广泛的抗癌药物。这种新的水溶性富勒烯 C-锰（II）三加合物配合物（III）在生物学、生物化学、医学和材料科学等领域具有广阔的应用前景。
