Cell-surface receptors in health and disease.

Assessment of interaction of hormones and neurotransmitters with their cell-surface receptors can lead to an understanding of the molecular mechanisms that underlie diseases in man involving resistance and supersensitivity to these humoral agents and to pharmacological agents. They can also lead to the development of simple diagnostic procedures for such disorders, as well as the development of radioreceptor assays for humoral agents and drugs in blood and tissues, assays which combine sensitivity comparable to those involving radiommunoassay with a greater biological accuracy.