Hernandez-Ronquillo Lizbeth, Miranzadeh Mahabadi Hajar, Moien-Afshari Farzad, Wu Adam, Auer Roland, Zherebitskiy Viktor, Borowsky Ron, Mickleborough Marla, Huntsman Richard, Vrbancic Mirna, Cayabyab Francisco S, Taghibiglou Changiz, Carter Alexandra, Tellez-Zenteno Jose F
Saskatchewan Epilepsy Program, Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Anatomy, Physiology and Pharmacology, College of Medicine University of Saskatchewan, Saskatoon, SK, Canada.
Front Neurol. 2020 Aug 20;11:833. doi: 10.3389/fneur.2020.00833. eCollection 2020.
Epilepsy comprises more than 40 clinical syndromes affecting millions of patients and families worldwide. To decode the molecular and pathological framework of epilepsy researchers, need reliable human epilepsy and control brain samples. Brain bank organizations collecting and supplying well-documented clinically and pathophysiologically tissue specimens are important for high-quality neurophysiology and neuropharmacology studies for epilepsy and other neurological diseases. New development in molecular mechanism and new treatment methods for neurological disorders have evoked increased demands for human brain tissue. An epilepsy brain bank is a storage source for both the frozen samples as well as the formaldehyde fixed paraffin embedded (FFPE) tissue from epilepsy surgery resections. In 2014, the University of Saskatchewan have started collecting human epilepsy brain tissues for the first time in Canada. This review highlights the necessity and importance of Epilepsy Brain bank that provides unique access for research to valuable source of brain tissue and blood samples from epilepsy patients.
癫痫包含40多种临床综合征,影响着全球数百万患者及其家庭。为了解码癫痫的分子和病理框架,研究人员需要可靠的人类癫痫和对照脑样本。收集并提供有充分临床和病理生理记录的组织标本的脑库组织,对于癫痫和其他神经疾病的高质量神经生理学和神经药理学研究至关重要。神经疾病分子机制的新进展和新治疗方法引发了对人类脑组织的更多需求。癫痫脑库是癫痫手术切除的冷冻样本以及甲醛固定石蜡包埋(FFPE)组织的储存来源。2014年,萨斯喀彻温大学在加拿大首次开始收集人类癫痫脑组织。本综述强调了癫痫脑库的必要性和重要性,它为研究提供了独特途径,以获取癫痫患者宝贵的脑组织和血液样本来源。