Wang Ge, Wu Wenyue, Xu Yuchen, Yang Zhuanyi, Xiao Bo, Long Lili
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Front Mol Neurosci. 2022 May 30;15:891621. doi: 10.3389/fnmol.2022.891621. eCollection 2022.
Epilepsy is a neurological network disease with genetics playing a much greater role than was previously appreciated. Unfortunately, the relationship between genetic basis and imaging phenotype is by no means simple. Imaging genetics integrates multidimensional datasets within a unified framework, providing a unique opportunity to pursue a global vision for epilepsy. This review delineates the current knowledge of underlying genetic mechanisms for brain networks in different epilepsy syndromes, particularly from a neural developmental perspective. Further, endophenotypes and their potential value are discussed. Finally, we highlight current challenges and provide perspectives for the future development of imaging genetics in epilepsy.
癫痫是一种神经网络疾病，遗传学所起的作用比之前认为的要大得多。不幸的是，遗传基础与影像学表型之间的关系绝非简单。影像遗传学在一个统一框架内整合多维数据集，为全面了解癫痫提供了独特契机。本综述阐述了不同癫痫综合征中脑网络潜在遗传机制的当前知识，特别是从神经发育的角度。此外，还讨论了内表型及其潜在价值。最后，我们强调了当前的挑战，并为癫痫影像遗传学的未来发展提供了展望。
