Li Liyan, Liu Shudong, Yu Junxia
Department of Endocrinology, First People's Hospital of Jinan, Jinan, People's Republic of China.
Department of Endocrinology, Shandong Rongjun General Hospital, Jinan, People's Republic of China.
Ther Adv Endocrinol Metab. 2020 Sep 14;11:2042018820958329. doi: 10.1177/2042018820958329. eCollection 2020.
Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.
自身免疫性甲状腺疾病（AITD）和1型糖尿病（T1DM）是两种可能同时发生的常见自身免疫性疾病。一般来说，糖尿病患者患AITD的风险较高。有人提出，复杂的遗传基础以及多种非遗传因素对T1DM和AITD的发病机制有不同程度的影响。在本文中，我们总结了该领域目前关于T1DM和AITD潜在致病因素的知识，包括人类白细胞抗原、自身免疫调节因子、淋巴细胞蛋白酪氨酸磷酸酶、叉头框蛋白P3、细胞毒性T淋巴细胞相关抗原、感染、维生素D缺乏和趋化因子（C-X-C基序）配体。这些发现为自身免疫性疾病的未来免疫治疗提供了思路。
