Kurian Christine J, Thomas Colin, Houtmann Sarah, Klumpp Thomas, Binder Adam Finn
Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, United States.
Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, United States.
Front Oncol. 2020 Aug 27;10:1497. doi: 10.3389/fonc.2020.01497. eCollection 2020.
Plasma cell dyscrasias and myeloproliferative neoplasms (MPN) are hematologic malignancies arising from two distinct hematopoietic cell lineages. They rarely occur concomitantly. Here, we report a case of a patient with a recent diagnosis of a JAK2 V617F positive MPN who presented with a new diagnosis of plasma cell leukemia. The patient had presented to the hospital with a leukocytosis predominantly comprised of plasma cells, followed by work-up involving peripheral blood flow cytometry, FISH analysis, and bone-marrow biopsy. FISH analysis was suggestive of a common progenitor cell for these distinct hematologic malignancies. To our knowledge, this case represents the second reported instance of a concomitant JAK2 positive MPN with primary plasma cell leukemia.
浆细胞异常增殖症和骨髓增殖性肿瘤（MPN）是起源于两种不同造血细胞谱系的血液系统恶性肿瘤。它们很少同时发生。在此，我们报告一例近期诊断为JAK2 V617F阳性MPN的患者，该患者同时被新诊断为浆细胞白血病。患者因以浆细胞为主的白细胞增多症入院，随后进行了包括外周血流式细胞术、荧光原位杂交（FISH）分析和骨髓活检在内的检查。FISH分析提示这些不同血液系统恶性肿瘤存在共同的祖细胞。据我们所知，该病例是第二例报告的同时患有JAK2阳性MPN和原发性浆细胞白血病的病例。
