Purwanto Diana Shintawati, Loho Tonny, Tafroji Wisnu, Mangunatmadja Irawan, Immanuel Suzanna, Timan Ina Susianti, Yusra Yusra, Safari Dodi
Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Department of Biochemistry, Faculty of Medicine Sam Ratulangi University, Manado, Indonesia.
Access Microbiol. 2020 Mar 26;2(5):acmi000123. doi: 10.1099/acmi.0.000123. eCollection 2020.
CNS infection is a life-threatening condition in developing countries and has been reported as the most common cause of bacterial meningitis; however, there is limited data on pneumococcal meningitis in Indonesia. This cross-sectional study aimed to isolate and identity strains from cerebrospinal fluid (CSF) specimens collected as part of routine testing from patients with clinically diagnosed central nervous system infection at a national referral hospital in Jakarta, Indonesia in 2017. isolation and identification were performed using conventional culture and molecular tools. Antibiotic susceptibility patterns were monitored through minimum inhibitory concentration testing. From 147 CSF specimens, one strain was identified from a patient with bacterial meningitis symptoms. The isolate was serotype 6B (ST5661) and susceptible to 18 antimicrobial agents tested, including penicillin, tetracycline, and the macrolide group. Our data provide insights into the epidemiology of invasive pneumococcal disease in Indonesia.
中枢神经系统感染在发展中国家是一种危及生命的疾病,据报道是细菌性脑膜炎最常见的病因;然而,关于印度尼西亚肺炎球菌性脑膜炎的数据有限。这项横断面研究旨在从2017年印度尼西亚雅加达一家国家转诊医院对临床诊断为中枢神经系统感染的患者进行常规检测时收集的脑脊液(CSF)标本中分离和鉴定菌株。使用传统培养和分子工具进行分离和鉴定。通过最低抑菌浓度测试监测抗生素敏感性模式。从147份脑脊液标本中,从一名有细菌性脑膜炎症状的患者中鉴定出一株菌株。该分离株为6B血清型(ST5661),对包括青霉素、四环素和大环内酯类在内的18种测试抗菌药物敏感。我们的数据为印度尼西亚侵袭性肺炎球菌疾病的流行病学提供了见解。