J Oral Facial Pain Headache. 2020;34(Suppl):s43-s56. doi: 10.11607/ofph.2583.
To investigate associations between experimental pain sensitivity and five chronic pain conditions among 655 participants in the OPPERA study.
Quantitative sensory tests were used to measure sensitivity to three modalities of nociception: blunt pressure pain, mechanical pinprick pain, and thermal heat pain. Participants were also classified according to the presence or absence of five chronic pain conditions: temporomandibular disorders, headache, low back pain, irritable bowel syndrome, and fibromyalgia.
Univariate analyses found each modality to be significantly associated with at least one pain condition, most consistently for pressure pain sensitivity (8 of 15 instances) and least consistently for heat pain sensitivity (5 of 35 instances). Yet, multivariable analyses that evaluated the independent contributions of all five pain conditions found few significant associations (12 of 75 instances). Instead, pain sensitivity consistently varied according to the total number of pain conditions a person experienced, implying that the combination of pain conditions influences each nociceptive modality.
When evaluating nociceptive sensitivity in a chronic pain patient, comorbid pain conditions should be considered, as the more salient feature underlying sensitivity is likely the number rather than the type(s) of pain conditions.
在 OPPERA 研究的 655 名参与者中，调查实验性疼痛敏感性与五种慢性疼痛状况之间的关联。
使用定量感觉测试来测量对三种伤害感受模态的敏感性：钝压疼痛、机械刺痛疼痛和热痛。参与者还根据是否存在五种慢性疼痛状况进行分类：颞下颌关节紊乱、头痛、下腰痛、肠易激综合征和纤维肌痛。
单变量分析发现每种模态都与至少一种疼痛状况显著相关，最一致的是压痛敏感性（15 次中有 8 次），最不一致的是热痛敏感性（35 次中有 5 次）。然而，评估五种疼痛状况独立贡献的多变量分析发现很少有显著关联（75 次中有 12 次）。相反，疼痛敏感性始终根据一个人经历的疼痛状况总数而变化，这表明疼痛状况的组合会影响每种伤害感受模态。
在评估慢性疼痛患者的伤害感受敏感性时，应考虑合并的疼痛状况，因为敏感性的基础更明显的特征可能是疼痛状况的数量而不是类型。
